Hypothetically speaking, what most probably would occur if a mass population of American citizens began pulling their money out of American banks and off the stock market
Or stopped spending on consumer goods even as they went up in price
Or borrowed money at high interest and invested in technology that didn't pan out and could not be repaid
Or if psychological panic hit the market, general buyers brokers and traders, via resonant mass communication like what the internet makes easy
Subsistence farmers, native Americans, high net worth gamblers betting against the grain by exiting the market early and rejoining to buy value assets for penny on the dollar prices, and diversified economic regions with multiple industries did better than the majority of people in the great depression
So did Hollywood, radio, and alcohol
Seems like the great depression was pretty good for the entertainment industry and bad for most everyone else
If you would like to make money during a great depression, consider investing in Soap, Nicotine, Cheaper Transportation Alternatives, Boxed and Canned Foods
Or maybe the answer is fresh dirt, clean seeds, natural tobacco leaf, and homegrown foods